About Advanced Chronic Heart Failure (CHF)
Advanced chronic heart failure (CHF) due to decreased heart pump function is a serious condition that happens when your heart muscle is damaged, becomes weak, and is unable to support the body’s need for adequate blood flow. In other words, your heart cannot keep up with the demands of your body with normal daily activity or even at rest.
Symptoms of chronic heart failure (CHF) include:
- Feeling very weak
- Fluid buildup, such as ankles, legs, or lungs
- Shortness of breath
- Loss of appetite
- Coughing, especially at night
- Chest pain
There is no single diagnostic test for advanced chronic heart failure (CHF). A diagnosis is based on your doctor’s clinical judgment after a physical examination, a review of your medical history, and other medical tests such as an echocardiogram (ultrasound of the heart), which may show a damaged area of the heart.
The Heart Failure Epidemic
In the U.S. alone there are:
- More deaths from heart failure than from all forms of cancer combined
- ~550,000 new cases of heart failure per year
- 6.4 million symptomatic heart failure patients as of 2014. This number is expected to increase by at least 20% to >8.0 million heart failure patients by 2030.
Measuring Heart Pump Function in
Patients with Chronic Heart Failure (CHF)
Sometimes heart failure can occur even with a normal measurement of the amount of blood that is being pumped from the heart. This happens if the heart muscle becomes excessively stiff from conditions such as high blood pressure rather than damage from a heart attack, as an example.
The DREAM HF-1 clinical trial is only enrolling patients with advanced chronic heart failure (CHF) who have heart muscle which is damaged, has become weak, and does not pump blood properly. In other words, their heart cannot keep up with the demands of their body.
Current Heart Failure Treatment Options
- Lifestyle changes such as quitting smoking, losing or maintaining weight, limiting alcohol consumption, eating a healthy diet, and exercising
- Medication, such as blood pressure medication, diuretics that remove excess fluids in your body, blood thinners, and cholesterol lowering drugs
- Cardiac rehabilitation such as a physical activity program tailored to your needs and limitations, counseling, and education to help you learn how to manage your condition
- Coronary Revascularization Therapy and/or Heart Valve Repair/Replacement-Devices and/or other surgical procedures such as Implantable Cardioverter-Defibrillator (ICD), Cardiac Resynchronization Therapy (CRT), placement of a left ventricular assist device (LVAD), artificial heart placement, or heart transplantation.